The first season, consisting of 22 episodes, introduces viewers to Lincoln Burrows, who is wrongly accused of murdering the Vice President's brother. His brother, Michael Scofield, a genius engineer, gets himself incarcerated in Fox River State Penitentiary to break Lincoln out. The season focuses on the intricate planning and execution of their escape, along with the introduction of other key characters such as Captain Brad Bellick (Wade Williams), Sara Tancredi (Sarah Wayne Callies), and Fernando Sucre (Amaury Nolasco). The season concludes with the successful escape of several inmates, setting the stage for the subsequent seasons.

The second season, also with 22 episodes, follows the escapees as they try to clear Lincoln's name and uncover the conspiracy behind his wrongful conviction. This season introduces new characters, including the mysterious and beautiful T-Bag (Robert Knepber), and sees the group facing numerous challenges as they evade capture and navigate their way through the United States. The season takes a significant turn with the introduction of the Company's existence, hinting at a larger conspiracy.

Prison Break followed the high-stakes journey of brothers Michael Scofield and Lincoln Burrows through five intense seasons and a concluding TV film. The series is celebrated for its intricate plotting, signature tattoos, and a revolving door of high-security prisons. Episode Count Primary Setting Season 1 2005–2006 22 Episodes Fox River State Penitentiary (Illinois) Season 2 2006–2007 22 Episodes On the run (Various U.S. states / Panama) Season 3 2007–2008 13 Episodes Sona Federal Penitentiary (Panama) Season 4 2008–2009 22 Episodes Los Angeles / Miami (Global Conspiracy) The Final Break Miami-Dade State Penitentiary Season 5 9 Episodes Ogygia Prison (Yemen) Season 1: The Breakout (22 Episodes)