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They combined isotope tracing with single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics. This allowed them to map gene expression and metabolic activity to specific cell types (cancer cells, T cells, macrophages, fibroblasts) and their physical locations within the tumor.
The most surprising conclusion of the study is the inversion of the glucose consumption paradigm. juq063
Based on this identifier, this corresponds to the significant paper titled , authored by Cody J. Carpenter et al., and published in Nature in 2024. and published in Nature in 2024.