A: In most cases, no. Adobe has retired the activation servers for CS6 and Acrobat XI. Even if you have a valid serial number, you typically cannot activate it on a new installation without contacting Adobe support (who will likely direct you to a subscription).
Since then, dozens of critical zero-day exploits have been discovered in the PDF rendering engine. If you open a malicious PDF from an email while using Pro XI, your computer can be compromised without you clicking anything except "Open." adobe acrobat pro xi
Do you still run Acrobat XI? Tell us your war stories in the comments below. A: In most cases, no